Having a hard time breaking off her engagement to Lenny, Zoey surveys her coworkers for the right breakup strategy. Jackie goes to the bathroom and snorts three lines of street-grade that she found in a patient's bag. On the journey back, Kevin finds out that Jackie took O'Hara's financial gift but thinks it is for the girls' education. Roman get some bad news. Prince sets out to help as many patients as possible before the hospital closes.
Jackie forges an organ donor authorization to make some good of a bike messenger's death, and punishes a violent sociopath with by flushing his severed ear down the toilet. Despite Jackie's complicated domestic life and obvious addiction, she is a surprisingly stable and strong character. Mo-Mo spends the night simultaneously deflecting Thor's advances and enjoying the fringe benefits of Thor's crush on him. Jackie is surprised by the return of Dr. Prince deteriorating before her eyes; Akalitus, after the hearing, takes a week off work; Eddie continues his dubious damage control; Carrie is further revolted by Karlsen. Seeing no other alternative Jackie attempts to flee New York but a car crash on her way to the airport prevents her from making her get away. Dr Roman informs Coop she is pregnant, and that he's the father.
After a sudden death in her home, Jackie realizes she needs to go to rehab; O'Hara gives Jackie some surprising news. O'Hara, as Jackie is expecting a job from Bellevue Hospital. Akalitus reprimands Zoey and Prentiss. An 80-year-old admitted for a tonsillectomy shares a bay with a 20-year-old candidate for hip replacement. Akalitus seeks Thor's help with a new phone system. Jackie gets tossed out of the mother-daughter dance lessons after a clash with a mother whom she knew from her high school days. Jackie enrolls Grace in public school.
At All Saints, Jackie's charged with shadowing Dr. Prince; Zoey and Carrie help Thor celebrate his wedding day. Details about O'Hara's famous girlfriend and Zoey's possible pregnancy come to light. Much like Jackie, O'Hara is contempt and bitter yet instantly likable. Eddie becomes an unwilling participant in the Peyton divorce battle.
Cooper's mother is admitted with a gall bladder attack and reveals a family secret about her son's upbringing. Eddie breaks boundaries and gets too close for comfort. Jackie dodges a drug screening at work, yet again. Nurse Jackie maybe lacklustre for fans of hard-hitting, edge-of-seat dramas, however the show is smart and gritty and certainly has potential. Prentiss talks to Akalitus about his relationship with Zoey. Heart problems make Zoey revisit her relationship with Lenny.
Zoey turns down Jackie's offer. Meanwhile, All Saints begins wrapping up its work on its final day. Jackie faces new challenges at home and at work with Grace's escalating anxiety and Jackie's increasingly conspicuous drug abuse. The show is centred around tough and candid Nurse Jackie who juggles her work, boyfriend, husband and kids all whilst dealing with her secret addiction to pain killers. Trying to solve the mystery of Akalitus' memory problem, Jackie slyly mandates a blood test for her. Edie Falco portrays every dimension of her character with real conviction. Cruz wants to make the hospital over into a trauma center with a helipad.
Roman try to keep their good news a secret. Cooper's last day at the hospital and Carrie might not be ready to say goodbye; The developers try to make a deal with Jackie; All Saints says hello to the new E. In rehab, Jackie escapes to a broom closet for some solitude, only to find the 17-year-old Charlie. Zoey breaks up with Lenny. O'Hara, in Jackie's absence, humorously struggles with the gushing, innocent gratitude of her young patient's twin brother. Jackie suddenly finds herself saddled with a sponsor.
Jackie finds a possible confidant at rehab in Charlie, a teen. Akalitus tries to readjust to being back on the floor as a nurse, while the other nurses feel torn about Quantum Bay's corporate swag. Akalitus posts a security guard by the Pill-O-Matix and approaches Dr. A pharmaceutical company rep provides Jackie with drugs. When she gets home, she finds a list of things Grace wants written on Grace's bedroom wall.